It sounds like, overall, the consistent advice was summed up well by Vasil Vasilescu:
Vasil Vasilescuspeed is life
I also noted the tips on how I should alter my process when pulled out of hyper.
Here's an updated EDSY plan for my Beluga. I focused on Power Distro and Engines, as suggested. Speed is now 305 with a boost to 427. I also tried to keep heat management in mind, so I made some adjustments elsewhere in the plan to keep things relatively cool despite the change to Dirty+Drag.
Obviously, I'm going to stick with the Beluga for this. With a capacity of 168, a loss of a dozen passengers is only 7%; which I think makes even a bad run worth it. (It might seem callous, if the in-game civilian lives lost were real, but they're not so I think playing the revenue game makes sense here.)