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James De Mille (23 August 1833 – 28 January 1880) was a professor at Dalhousie University, Nova Scotia, and an early Canadian popular writer who published numerous works of popular fiction from the late 1860s through the 1870s.

He was born in Saint John, New Brunswick, son of the merchant and shipowner, Nathan De Mille. He attended Horton Academy in Wolfville and spent one year at Acadia University. He then travelled with his brother Elisha Budd to Europe, spending half a year in England, France and Italy. On his return to North America, he attended Brown University, from which he obtained a Master of Arts degree during 1854. He married Anne Pryor, daughter of the president of Acadia University, John Pryor, and was there appointed professor of classics. He served there until 1865 when he accepted a new appointment at Dalhousie as professor of English and rhetoric. He continued to write and teach at Dalhousie until his early death at the age of 47.