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Jean-Dominique, comte de Cassini (30 June 1748 – 18 October 1845) was a French astronomer, son of César-François Cassini de Thury.

Cassini was born at the Paris Observatory. In 1784, he succeeded his father as director of the observatory; but his plans for its restoration and re-equipment were wrecked in 1793 by the animosity of the National Assembly. His position having become intolerable, he resigned on 6 September and was thrown into prison in 1794, but released after seven months. He then withdrew to Thury, where he died in 1845.