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Juan Ponce de León (Spanish pronunciation: [xwam ˈponθe ðe leˈon]; 1474 – July 1521), commonly known as Ponce de León (, also UK: , US: ), was a Spanish explorer and conquistador known for leading the first official European expedition to Florida and the first governor of Puerto Rico. He was born in Santervás de Campos, Valladolid, Spain in 1474. Though little is known about his family, he was of noble birth and served in the Spanish military from a young age. He first came to the Americas as a "gentleman volunteer" with Christopher Columbus's second expedition in 1493.

By the early 1500s, Ponce de León was a top military official in the colonial government of Hispaniola, where he helped crush a rebellion of the native Taíno people. He was authorized to explore the neighboring island of Puerto Rico in 1508 and for serving as the first Governor of Puerto Rico by appointment of the Spanish crown in 1509. While Ponce de León grew quite wealthy from his plantations and mines, he faced an ongoing legal conflict with Diego Columbus, the late Christopher Columbus's son, over the right to govern Puerto Rico. After a long court battle, Columbus replaced Ponce de León as governor in 1511. Ponce de León decided to follow the advice of the sympathetic King Ferdinand and explore more of the Caribbean Sea.