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Carl Friedrich Freiherr von Weizsäcker (June 28, 1912 – April 28, 2007) was a German physicist and philosopher. He was the longest-living member of the team which performed nuclear research in Germany during the Second World War, under Werner Heisenberg's leadership. There is ongoing debate as to whether or not he, and the other members of the team, actively and willingly pursued the development of a nuclear bomb for Germany during this time.

A member of the prominent Weizsäcker family, he was son of the diplomat Ernst von Weizsäcker, elder brother of the former German President Richard von Weizsäcker, father of the physicist and environmental researcher Ernst Ulrich von Weizsäcker, and father-in-law of the former General Secretary of the World Council of Churches Konrad Raiser.