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Ewine van Dishoeck (born 13 June 1955 in Leiden) is a Dutch astronomer and chemist. She is Professor of Molecular Astrophysics at Leiden Observatory.

She is a member of the Royal Dutch Academy of Sciences and the U.S. National Academy of Sciences. She received the Gothenburg Lise Meitner Award in 2014, the Spinozapremie in 2000, the Bourke Award of the Royal Society of Chemistry (UK) in 2001 and the Gold Medal of the Royal Dutch Chemical Society in 1994. She works on interstellar molecules; physical and chemical evolution during star formation and planet formation; submillimeter and mid-infrared astronomy; basic molecular processes; and the radiative transfer of line and continuum radiation.

She was a Junior Fellow of the Harvard Society of Fellows.

Van Dishoeck is married to Tim de Zeeuw, also a professor of astronomy at Leiden University and, as of September 2007, Director General of the European Southern Observatory.